We can work on Reflective journal

Description

The purpose of these journaling activities is for you to reflect upon, and write (or record a video/audio file in Canvas) about, what you are learning and experiencing in this class. It is also your chance to “talk” with me as your professor, discuss your progress, and ask any questions that you may have. For this journal activity, please use the questions below to guide your writing. I expect you to write at least ½ to 1 page of narrative.

GUIDING QUESTIONS:

1) Now that you have had a chance to try the HardiCoping techniques of: a) Situational Reconstruction, b) Focusing, and c) Compensatory Self-Improvement, briefly describe how each of these techniques worked for you.

2) Which hardicoping technique did you prefer and why did you prefer it?

3) How have your experiences in this class to date helped you develop and strengthen your attitudes of commitment (I am worthwhile.), control (I am capable.), and challenge (I am learning.)?

4) Do you have any questions and/or insights you’d like to share?

Sample Solution

Stroke is taken into consideration to be the 1/3 reason of death and incapacity for millions of human beings in advanced international locations (1). Stroke is the scientific manifestation of a wide range of pathologies, with exceptional etiologies and prognoses, and plenty of hazard elements. Stroke is described as a syndrome characterised through hastily developing medical signs and/or symptoms of focal loss of cerebral characteristic, wherein symptoms final greater than 24 hours or result in death, with out a apparent reason other than that it’s far a vascular starting place. Stroke victims who live on the first attack might also have persisting impairments together with cognitive impairments, top and lower limb impairments and speech disabilities. the UK’s prevalence of stroke within the population is expected to be 47 in line with 10000 making stroke the maximum common motive of person physical disability (1; 2; three). within the United state the Veterans fitness administration (VHA) expected that 15000 veterans are in hospitals with a analysis of stroke every 12 months (4). Stroke rehabilitation is a main element in assisting stroke survivors to regain their practical potential whilst medical and surgical interventions are restricted (five). physical remedy plays a prime function in stroke rehabilitation. physical therapists select the length and kind of therapy given and provide schooling for stroke patients. Stroke rehabilitation pursuits at giving the sufferers the potential to regain maximum and complete ability in purposeful activities and healing of motor manipulate (6; 7; 8; five). three main factors in rehabilitation make contributions to the speed and excellent of restoration. those factors are: remedy session length and frequency, form of remedy technique used for rehabilitation, and presenting training about the situation for sufferers during and after therapy (2; 3; 7; eight; nine). bodily therapy rehabilitation for stroke patients is designed to effect the disabilities and impairments associated with publish stroke conditions. Rehabilitation is especially aimed at limiting any deterioration of impairments and maximizing the useful stage for patients affected by stroke. in an effort to deliver this, physical therapists ought to comply with a positive set of suggestions to be able to insure better results and keep away from unnecessary practices that would prolong and delay finest advantage of feature (6; 7). it’s miles unclear whether or not physical therapists in Kuwait follow any unique recommendations in stroke rehabilitation. therefore, it might be doable to analyze extra about current nearby rehabilitation procedures. this can help inside the in addition improvement of nearby rehabilitation processes and practice guidelines, optimization of remedy and rehabilitation control, development in stroke affected person’s health and great of lifestyles, and minimization of conflicted rehabilitation practices that extend remedy which in flip affect and burden the health gadget with expanded quantity of sufferers (6; eight; 10; eleven). We hypothesize that bodily therapist in Kuwait rehabilitation do no longer follow stroke rehabilitation suggestions and science primarily based practices in stroke rehabilitation. therefore the pursuits of this examine are to: explore if stroke rehabilitation in Kuwait follow standard guidelines of stroke rehabilitation regarding frequency of remedy classes and period of every session. look at if bodily therapists specializing in the area of neuroscience in Kuwait follow wellknown recommendations of stroke rehabilitation concerning their treatment processes. discover if training is being supplied for stroke patients approximately their situation during and after rehabilitation. Literature overview: Stroke is described as a syndrome in which clinical symptoms and/or signs of cerebral characteristic loss broaden hastily, and final for more than 24 hours or bring about loss of life. Stroke may be categorized according to the purpose, that’s either ischemic or hemorrhagic. Ischemic strokes account for 85% of all strokes, at the same time as 15% account for hemorrhagic strokes. Over 10% of sufferers who had a primary stroke may have a 2d one inside a year, and the risk of recurrence within five years is 15-42% (1). There are a extensive variety of situations that lead to stroke, including high blood pressure and diabetes. each 12 months, 5.45 million deaths are attributed to stroke, and over 9 million survive. Survivors frequently enjoy a huge variety of persisting impairments. common impairments consist of physical incapacity, cognitive impairment, lower limb impairments, and speech difficulties (1). Rehabilitation is an critical element after survival from a stroke. Rehabilitation become defined within the New Zealand guiding principle for control of stroke as ‘a hassle-solving and educational method aimed at reducing the disability and handicap skilled with the aid of someone as a result of disorder, continually inside the obstacles imposed through both to be had sources and the underlying disease’ (12). It’s of maximum significance that the stroke affected person is aware, and receives schooling regarding his/her condition and what boundaries may additionally persist, even after rehabilitation (12). Reker D. M. et al, researched whether adherence to post stroke suggestions became related to extra affected person delight. They used a prospective inception cohort study layout for new stroke admissions, inclusive of submit-acute care, and they made comply with-up interviews at 6 months after the stroke injury. two hundred and 80 eight sufferers had been covered inside the look at, from 11 Veterans Affairs clinical facilities (VAMCs). the primary outcome measures used on this observe have been: 1) compliance with the corporation for Healthcare studies and satisfactory (AHRQ), 2) affected person pleasure with care supplied, and 3) stroke-unique gadgets. consequences have shown that, for every 10% percent growth in tips compliance, the common cost of affected person delight will increase with the aid of 1.five factors for the suggest usual pleasure rating, which ranges from 4 to 39, and includes objects for hospital pleasure, home pleasure, and standard pride. The take a look at concluded that compliance to AHRQ guidelines is notably associated with affected person delight (7). numerous comparisons between Stroke Rehabilitation Protocols/ hints were finished. that is useful in setting up the exceptional remedy, as regards to dosing, depth, duration, in addition to performance and efficacy of interventions. A take a look at by way of McNaughton H, et al tested the practice and effects of stroke rehabilitation among New Zealand and america centers. This have a look at used a potential observational cohort layout and protected 1161 individuals from six america (U.S.) Rehabilitation facilities and one hundred thirty participants from one New Zealand rehabilitation facility, all above the age of 18 years. on this study, New Zealand patients have been older than america sufferers. but, the severity of initial stroke was higher for the U.S. patients. no matter that reality, sufferers inside the U.S. had been discharged earlier. they also had greater in depth therapy, represented in better durations spent with bodily therapy and occupational therapy specialists. also, united states of americatherapists tended to spend much less time on evaluation and non-purposeful activities, even as focusing greater on active control of sufferers. effects confirmed that, U.S. contributors had higher results represented through adjustments in practical Independence degree FIM scores and less discharges to institutional care (thirteen.2% vs. 21.5%). This examine illustrates that period and intensity of remedy may be adjusted to gain a higher final results. also, it is vital to recognize which activities are being finished inside the remedy consultation, and find out if they make a contribution to a higher outcome of rehabilitation (10). Horn et al. investigated the impact of unique rehabilitation healing procedures in stroke rehabilitation on consequences, taking into consideration the variations among patients. in this examine, they wanted to study the institutions between patient characteristics, rehabilitation treatments, neurotropic remedy, nutritional help, and time of starting therapy with practical consequences and discharge vacation spot for stroke inpatients. Discharge overall, motor, and cognitive FIM (practical independence measure) rankings and discharge destinations had been registered for 830 patients with slight or intense strokes from five U.S. inpatient rehabilitation centers. outcomes showed that earlier initiation of rehabilitation, time spent in higher-degree rehabilitation activities, which include higher-extremity manipulate, gait and problem solving, usage of newer psychiatric medications, and gastric feeding, have been all related to better results. The examine additionally illustrated that a spread of bodily remedy, Occupational remedy, and Speech Language Pathology activities have been correlated with better or decrease FIM rankings. On one hand, greater minutes spent consistent with day on PT gait sports, OT higher-extremity manipulate activities and domestic control, and SLP hassle solving activities had been associated considerably with better FIM scores. however, greater minutes spent according to day on PT mattress mobility and sitting, OT mattress mobility, and SLP auditory comprehension and orientation have been constantly related to lower FIM ratings (eleven). One examine defined physical remedy intervention for stroke patients in inpatient centers inside the U.S. (13). Six rehabilitation facilities inside the U.S. protected 972 topics with stroke harm. Variables studied were time spent in therapy, and content and sports that have been used in rehabilitation. The imply duration of stay in the inpatient facilities was 18.7 days, and acquired PT changed into on a mean of thirteen.6 days. affected person spent 57.15 minutes on average for physical remedy treatment each day. sports of gait, shifting, and pre-purposeful activities, which include strengthening exercises, balance education, and motor gaining knowledge of, were the maximum accomplished interventions. also, therapists covered sports that integrated one of a kind capabilities into one purposeful interest. This examine implicated that a focus of bodily therapist while imparting remedy is optimizing functional activities, as they have been the maximum common sports carried out. but, activities to remediate impairments and to atone for misplaced functions have been also protected in the treatment periods (13). Brocklehurst et al. investigated the usage of bodily therapy, occupational remedy, and speech therapy for sufferers stricken by stroke, as they referred to that the ones interventions fashioned the basis of stroke rehabilitation. The take a look at blanketed one hundred thirty five stroke sufferers from 5 general and one geriatric sanatorium, in South Manchester. Of the 135 topics, 107 acquired PT, 35 received OT, and 19 obtained speech remedy. outcomes had been acquired after measuring the rate of exchange in characteristic over a three hundred and sixty five days length. patients, who had extra extreme disabilities, and the worst diagnosis, were much more likely to get physical therapy treatment. elements that decide kind and specificity of physical therapy to stroke rehabilitation were additionally examined. some of the elements had been volume of disability, and incapacity-associated morbidities, along with fecal incontinence, spasticity, sensory loss and dysphasia. despite the fact that the maximum disabled acquired the most physical therapy remedy, they showed the least development in function even after six months of remedy. This take a look at additionally concluded that patients, whose progress was poorest, obtained more bodily remedy (five). Hsiu-Chen Huang et al. investigated the impact of timing and dose of rehabilitation shipping on the purposeful recuperation of patients tormented by stroke. in this observe, a retrospective review of clinical charts turned into executed for seventy six patients who have been admitted to a nearby health facility for a first-ever stroke. sufferers had multidisciplinary rehabilitation packages, which includes PT, OT, and a continuous rehabilitation for at least three months. the primary final results measure for this study changed into the Barthel index, taken at preliminary evaluation, one month, three months, six months and 365 days after stroke. results of this have a look at confirmed that there may be a dose-dependent effect of rehabilitation on functional outcome upgrades of stroke sufferers. additionally, earlier delivery of rehabilitation is associated with lasting outcomes on useful restoration up to twelve months put up-stroke (14). it’s miles unclear whether physical therapists comply with proof based practice many countries of the sector such as Kuwait. there is no doubt the generation of evidence based exercise is upon us for many motives along with higher remedy outcomes, affected person satisfaction, compensation amongst others. in one survey look at, conducted by Iles and Davidson, exam of physical therapists’ current exercise in Australia become undertaken. This look at determined that there are numerous barriers within the way of proof-based practice. the ones boundaries covered time to live up to date, get right of entry to to journals, access to summaries of evidence which are smooth to understand, and absence of personal talents in looking for and evaluating studies proof (15). Salbach et al. tested the determinants of studies use in clinical choice making among bodily therapists treating publish-stroke sufferers. two hundred and sixty three bodily therapists from the state of Ontario, Canada, spoke back to a survey questionnaire, containing gadgets for comparing practitioner and organizational characteristics and belief of studies believed to be influencing proof-primarily based practice. The survey additionally contained the frequency of using research evidence in clinical selection making in a standard month. consequences confirmed that, only a small percent of therapists (thirteen.33%) reported the use of studies in clinical decision making six times a month or greater. but, most therapists (52.9%) said the usage of research 2-5 times a month, while 33.eight% used studies zero-1 time per month. in this take a look at, research use become related to the instructional practise inside the principles of proof-based practice (EBP), studies participation, carrier as a scientific trainer, being self-effective in enforcing EBP, mindset toward studies, perceived organizational support of studies use, and get admission to to bibliographic databases at paintings. This take a look at concluded that a third of therapists rarely apply studies proof in medical selection making. counseled interventions to promote research use blanketed training in the standards of EBP, EBP self-efficacy, having a tremendous attitude closer to research, and involvement in studies (8). A observe with the aid of Ogiwara, made a assessment among the bases of treatment among jap bodily therapists, and Swedish therapists. They investigated the motives why the japanese pick out positive approaches of remedy while managing stroke patients, and then as compared the consequences with the ones of Swedish therapists. Swedish therapists attributed their preference of treatment to hands-on enjoy and participation in practical publications, in which numerous techniques are taught. Bobath’s method was the simplest approach that became commonly persisted to be used after commencement in both nations. outcomes have illustrated that Swedish therapists have been extra inquisitive about new strategies of remedy (ninety one%), while only 77% of japanese therapists had an interest. Implication in their outcomes would possibly suggest that jap therapists are inquisitive about their treatment technique, and also display that introducing new tactics of treatments takes a longer time in assessment to Sweden. moreover, Swedish therapists tend to make a mixture of treatment strategies, at the same time as japanese physical therapists tend to observe simplest one unique approach. numerous motives have been speculated for addressing the differences in remedy protocols, some of which had been: 1) variety of cultures, 2) variety of health the care device, 3) availability of gadget and space had to follow a positive new method, 4) perception of efficacy of a positive method and five) the language barrier imposed on japanese therapist, and availability of translated literature. This examine confirmed that there are several barriers and differences encountered while the need of utility of recent procedures is favored (9). Wachters-Kaufmann et al. carried out a observe regarding the conferring of facts for stroke patients and caregivers. Their study investigated how records was furnished to sufferers and caregivers and how they without a doubt favored to be informed. The real and preferred records correspond in terms of content material, frequency, and method of displays properly because the actual and favored information. The study changed into carried out inside the North of the Netherlands and the stroke unit of university health facility Groningen. the overall practitioners (GP) disbursed a guide from a community-based observe of cognitive problems and first-class of life (CognitiVA) after a stroke. The guide was given 3 months after the stroke. For the final size of the have a look at, which changed into one year later, the patients and caregivers participated in a cellphone survey, which requested about three things: 1) professional stroke-care companies, 2) other assets of statistics, 3) the manual. 51 patients and 38 caregivers have been contacted, of which 18 patients and 11 caregivers declined to be interviewed for diverse reasons. The outcomes showed that the GP’s, neurologist, and physical therapists had been both the real and favored facts carriers. As for the content material, the real content changed into the manual, while the preferred changed into often medical statistics regarding the route of the disease, its reason, outcomes, and remedy. concerning the frequency, the actual and desired become inside 24 hours of the stroke, and in the future to 2 weeks later, and after weeks. As for the technique of presentation of statistics, the sufferers and caregivers normally preferred handiest verbal (seventy three% sufferers, 89% caregivers) (sixteen). methods: This comparative layout studies assignment will compare the stroke rehabilitation software carried out in Kuwait with the hooked up recommendations for stroke rehabilitation inside the u.s.a. of america. The rehabilitation application stroke patients are receiving in Kuwait’s Ministry of fitness hospitals, mainly, Al-Jahra, Mubarak, Farwanya, bodily remedy and Rehabilitation, and Al-Sabah hospitals might be investigated. subjects of the take a look at could be physical therapists practising in the stroke rehabilitation discipline. we can provide physical therapists skilled in stroke rehabilitation with self-administered questionnaires, to be able to be gathered after one week. we can additionally look at patient statistics over a 3 week period. To get admission to the statistics, we are able to get permission from the top of the physical therapy branch of each health facility in addition to each hospitals director. Institutional assessment Board (IRB) approval will be received previous to any records collection. Approval from the Ministry of fitness’s IRB could be obtained as well as approval from Kuwait university. statistics will then be in comparison with the mounted American Stroke recommendations. All facts collected at some stage in the look at may be saved underneath lock and key. Any identifiable facts acquired from affected person documents and records will most effective be on hand to the number one investigator. No identifiable facts may be used for publication purposes. Confidentiality could be insured at some point of the have a look at duration. subjects: The topics of this look at may be physical therapists working in Kuwait’s Ministry of health hospitals’ neurology department and with experience in out-patient stroke rehabilitation. equipment: to research the frequency and length of treatment, we are able to look at the data, which can be the sufferers’ documents. there is also a section inside the questionnaire with a purpose to ask about the frequency and length of classes. As for finding out the treatment approach patients are receiving, a self-administered questionnaire could be distributed at selected MOH hospitals, particularly at Al-Jahra, Mubarak, Farwanya, bodily medicine and Rehabilitation, and Al-Sabah hospitals. Therapists could be given the questionnaire to fill out. as a way to examine the type of schooling given to sufferers, instructional publications, or pamphlets, about the patient’s circumstance available at the sanatorium and distributed to sufferers may be looked at. The questionnaire will even ask approximately exceptional patient education techniques utilized by the participants. For comparison of records, we will evaluate the records we reap with the yankee Stroke association pointers. Questionnaire: The questionnaire will consist of numerous questions used inside the Ogiwara (9) questionnaire as well as others pertinent to our look at populace. The questionnaire will include 4 elements: demographic information questions regarding the therapist’s professional records and revel in Questions concerning the rehabilitation software: treatment approach, and frequency and duration of periods. questions regarding the kinds of training strategies each questionnaire could have a cowl letter explaining the cause of the study, and a consent form. facts analysis The statistics might be analyzed the usage of SPSS (Statistical bundle for Social Sciences) (v. 17.0) to explain way, popular deviations, frequencies, and probabilities. once the statistics is analyzed, we will evaluate the facts we amassed with the overall hints and remedy approaches within the literature. anticipated outcomes and pointers Our expectation for this have a look at is that physical therapists in the nation of Kuwait will no longer be following the american stroke rehabilitation guidelines. because of cultural differences between the two countries, establishing new suggestions for the stroke rehabilitation in Kuwait might be necessary, addressing the character of referral to physical therapy in Kuwait, and making tips for increasing treatment period if wanted. additionally, it ought to be noted what form of unique equipment is probably used inside the technique of rehabilitation. References: Rudd A, Olfe C.W. (2002, Feb). Aetiology and pathology of stroke. Vol. nine, pg 32-36. Hafsteinsdottir T.B, Vergunst M, Lindeman E, Schuurmans M. (2010, 29 July). instructional desires of sufferers with a stroke and their caregivers: a systematic overview of the literature. www.elsevier.com/discover/pateducou Hoffman T, McKenna ok, Herd C, carrying S. Written stroke materials for stroke patients and their careers: views and practices of fitness experts. pinnacle Stroke Rehabil 2007;14(1):88-97 Duncan P, Zorowitz R, Bates B, Choi J, Glasberg J, Graham G, Katz R, Lamberty k, Reker D. management of grownup Stroke Rehabilitation Care: A clinical exercise tenet. (Stroke. 2005; 36:e100-e143.) Brocklehurst J.C, Andrews okay, Richards B, Laycock P. J. (1978, 20 may additionally). How a good deal physical therapy for sufferers with stroke? Vol. 1, 1307- 1310. British scientific journal. Kollen, B, Kwakkel G, Lindeman E. (2006, eleven July). practical recovery after Stroke: A review of present day developments in Stroke Rehabilitation studies. Vol.1, No.1, 75-80. Reker D.M, & Duncan P. W, Horner R.D, Hoenig H, Samsa G.P, Hamilton B, Dudley T.k.(2002, June) put up acute Stroke tenet Compliance Is related to more affected person satisfaction. Arch Phys Med Rehabil Vol. eighty three, pg 750-756. Salbach N, Guilcher S, Jaglal S, Davis A. (2010) Determinants of studies use in medical decision making among bodily therapists supplying services put up-stroke: a cross-sectional study. http://www.implementationscience.com/content material/5/1/77 Ogiwara S. (1997) bodily remedy in stroke rehabilitation: A comparison of bases for remedy among Japan and Sweden.vol.9 Pg. 63-69, magazine of physical therapy sciences. McNaughton H, DeJong G, Smout J, Melvin L, Brandstater M. (2005, Dec) A evaluation of Stroke Rehabilitation practice and consequences among New Zealand and u.s.a. centers. Vol. 86, suppl.2, Arch Phys Med Rehabil. Horn D, DeJong G. Smout J, Gassaway J, James R, Conroy B. (2005, Dec) Stroke Rehabilitation patients, exercise, and outcomes: Is earlier and more aggressive therapy better? Vol. 86, pg. a hundred and one-114, suppl. 2, Arch Phys Med Rehabil. life after stroke: New Zealand guiding principle for management of stroke (November 2003). Jette D.U, Latham N.k, Smout R.J, Gassaway J, Slavin M.D, Horn S.D (2005, March) physical remedy Interventions for sufferers with Stroke in Inpatient Rehabilitation centers. Vol. eighty five, num. 3, pg. 238-248, bodily remedy. Huang H, Chung k, Lai D, Sung S. The impact of Timing and Dose of Rehabilitation delivery on functional restoration of Stroke patients (J Chin Med Assoc: may 2009 , Vol 72, No 5) Iles R, Davidson M. proof based exercise: a survey of physiotherapists’ current practice. physical therapy. Res. Int. 11(2) ninety three-103 (2006) Watchers-Kaufmann C, Schuling J, The H, Jong B. actual and preferred information provision after a stroke. affected person training and Counseling fifty six (2005) 211-217 Appendices Appendix 1 American Stroke association recommendations: E. patient and own family/Caregiver training heritage The affected person and own family/caregivers should receive records and provided with an opportunity to study the causes and results of stroke, ability headaches, and the desires, procedure, and analysis of rehabilitation. guidelines endorse that affected person and circle of relatives/caregiver education be provided in an interactive and written layout. advocate that clinicians take into account identifying a particular team member to be liable for supplying statistics to the affected person and circle of relatives/caregiver about the character of the stroke, stroke control rehabilitation and outcome expectancies, and their roles inside the rehabilitation manner. recognize that the family conference is a beneficial manner of statistics dissemination. endorse that affected person and circle of relatives education be documented within the patient’s medical document to prevent the prevalence of replica or conflicting information from one-of-a-kind disciplines. N. teach affected person/own family, attain Shared selection about Rehabilitation program, and decide treatment Plan objective ensure the expertise of not unusual goals among workforce, family, and caregivers inside the stroke rehabilitation process and, consequently, optimize the patient’s functional restoration and community reintegration. suggestions recommend that the medical team and circle of relatives/caregiver reach a shared decision about the rehabilitation software. Â Â Â The clinical team ought to endorse the preferred surroundings for rehabilitation and treatments on the premise of expectations for recuperation. Â Â Â Describe to the affected person and family the treatment alternatives, which includes the rehabilitation and recuperation method, diagnosis, anticipated length of stay, frequency of remedy, and discharge criteria. Â Â Â The patient, own family, caregiver, and rehabilitation group need to decide the surest environment for rehabilitation and favored treatment. advise that the rehabilitation application be guided through specific goals developed in consensus with the affected person, circle of relatives, and rehabilitation crew. suggest that the patient’s family/caregiver take part inside the rehabilitation classes and learn to assist affected person with purposeful activities, whilst wanted. endorse that patient and caregiver training be supplied in an interactive and written layout. provide the patient and family with an records packet that may consist of published material on topics such as the resumption of riding, affected person rights/obligations, assist organization information, and audiovisual packages on stroke. suggest that the special remedy plan be documented inside the patient’s document to provide incorporated rehabilitation care. intensity of remedy The heterogeneity of the research in all aspects-patients, designs, remedies, comparisons, final results measures, and results-mixed with the borderline effects in most of the trials limits the specificity and power of any conclusions that can be drawn from them. average, the rigors aid the overall idea that rehabilitation can improve purposeful outcomes, mainly in sufferers with lesser ranges of impairment. susceptible proof exists for a dose-response dating between the depth of the rehabilitation intervention and the purposeful results. however, the shortage of definition of lower thresholds, below which the intervention is vain, and upper thresholds, above which the marginal development is minimum, for any treatment, makes it impossible to generate unique suggestions. Partridge et al did not discover any variations in functional and psychological scores at 6 weeks in 104 patients randomized between a popular of 30 and 60 minutes of bodily remedy. Kwakkel et al randomized a hundred and one center-cerebral-artery stroke sufferers with arm and leg impairment to extra arm education emphasis, leg schooling emphasis, or arm and leg immobilization, every treatment lasting half-hour, five days a week, for 20 weeks. At 20 weeks the leg schooling organization scored better for ADLs, walking, and dexterity than the control institution, whereas the arm education group scored higher only for dexterity. The scientific trials provide vulnerable proof for a dose response relationship of depth to functional consequences.>

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