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Malaria is a life-threatening disease and is widespread in the tropical and subtropical regions mainly around the equator. Malaria is a protozoan disease and transmitted through infected female anopheles mosquitoes. Malaria parasite is require two hosts to complete their life cycle; one is definitive host (Sexual cycle) in Anopheles mosquito and second intermediate host (Asexual cycle) in human. Haploid parasite adopts three different cellular strategies in the distinct phases of the complex life cycle. In the human, schizogony (Asexual reproduction) occurs and this schizogony is found as two types, one erythrocytic schizogony ‘ found in erythrocytes and second exo-erythrocytic schizogony ‘ found in other tissues (Liver). There are 430 species of Anopheles mosquitoes, and out of these, 58 species are identifying in India. Seven of these have been known as the main malaria vectors in India, namely An. culicifacies, An. dirus, An. fluviatilis, An. minimus, An. Sundaicus, An. Stephensi and An. Philippinesis.. Epidemiology of malaria Globally, an estimated 3.4 billion people are at risk of malaria. WHO estimates that 207 million cases of malaria occurred globally in 2012 and 627 000 deaths. Most cases deaths reported in Africa and under 5 years children were in most deaths (77%) (WHO malaria report 2013). In South East Asia (SEA) contributed only 3.9% malaria burden in globally but India is contributing alone more 50% reported malaria cases from SEA followed by Myanmar (24%) and Indonesia (22%).>

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