Order Description
Watch this video and then summarize the scientific points the doctor raised.

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7.2. NNT
The effects of statins in people aged between 30 and 84 years were investigated using a prospective cohort study. Data were taken from the QResearch database, a computerized database of anonymised
longitudinal medical records collected prospectively in primary care. A cohort of patients registered with general practices between 1 January 2002 and 30 June 2008 was used. New users of statins
were compared with non-users.

The intended effects of statins was a reduction in the occurence of cardiovascular disease. The number needed to treat for cardiovascular disease over 5 years was 37 (95%CI 24-57) for men. Acute
renal failure was a side effect of statins: the number needed to harm was 434 (95%CI 284-783) for women and 593 (95%CI 388-1070) for men.

Select one of the statements below, categorize it as true or false and explain why.
7.2. A) The number needed to treat is the number of individuals who need to be treated with statins over five years for one to experience cardiovascular disease.
7.2. B) The number needed to harm is the number of individuals that would need to be treated with statins over five years for one more person to experience acute renal failure than would have been
observed if the same number of individuals had not received treatment.
7.2. C) A small number needed to harm is desirable.
7.2. D) The uncertainty of the number needed to treat as an estimate of the population parameter is quantified by the 95% confidence interval.

7.3. NNT II
In the figure below, clozapine and other second generation antipsychotics are compared in terms of all cause discontinuation rates.

7.3. A) What does the NNT CI that includes a negative number (in comparison with olanzapine) imply?
7.3. B) Why is the graph centred on infinity instead of zero?